Stage IIA
Stage IIB
Current Clinical Trials

Many combinations of preoperative intracavitary and external-beam radiation therapy (EBRT) with hysterectomy and bilateral salpingo-oophorectomy are used for treatment of stage II endometrial cancer, with careful biopsy of the para-aortic nodes at the time of surgery. When microscopic cervical stromal involvement is found, postoperative radiation therapy (EBRT and vaginal radiation therapy) should be used.

Stage IIA (endocervical glandular involvement only) should be treated the same as stage I disease.

Standard treatment options:

1. Hysterectomy, bilateral salpingo-oophorectomy, and node sampling followed by postoperative radiation therapy.
2. Preoperative intracavitary and EBRT followed by hysterectomy and bilateral salpingo-oophorectomy. (A biopsy of the para-aortic nodes should be done at the time of surgery.)
3. Radical hysterectomy and pelvic lymphadenectomy in selected cases.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II endometrial carcinoma ¹. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site ².