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31. News Notes: Structure of Bacteria Related to Traveler's Diarrhea Could Have Implications for Cancer Vaccine Development
(Posted: 06/08/2009) - NCI researchers and colleagues have determined the structure of thin hair-like fibers on the surface of a type of E. coli bacteria that is the most common culprit in traveler's diarrhea. The scientists, from NCI's Center for Cancer Research, using atomic resolution technology, have elucidated the mechanics of assembly of these fibers as they exit cells through a pore on the bacterial surface.
32. News Note: Pesticide Use Linked to Higher Risk of Pre-Cancerous Multiple Myeloma
(Posted: 05/29/2009) - Investigators from NCI used data from the Agricultural Health Study to refine and expand a relationship between pesticide exposure and risk for multiple myeloma that they had established several years ago. They found that men who used pesticides occupationally, particularly farmers, had a nearly two-fold increased risk of a well-established precursor for multiple myeloma compared to men not exposed to pesticides through their job.
33. Researchers Identify Biological Markers that May Indicate Poor Breast Cancer Prognosis
(Posted: 05/26/2009) - A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation. Using data from the Health, Eating, Activity and Lifestyle (HEAL) study sponsored by the NCI, the researchers found that breast cancer patients with elevated levels of C-reactive protein (CRP) and serum amyloid A (SAA) were approximately two to three times more likely to die sooner or have their cancer return than those patients who had lower levels of these proteins, regardless of the patient's age, tumor stage, race, body mass index, or history of previous cardiovascular issues.
34. Formaldehyde Exposure among Industrial Workers Is Associated with Increased Risk of Cancers of the Blood and Lymphatic System
(Posted: 05/12/2009) - Results from an ongoing study of workers employed at plants that used or produced formaldehyde continue to show a possible link between formaldehyde exposure and death from cancers of the blood and lymphatic system, particularly myeloid leukemia. The report, by researchers at the NCI provides an additional 10 years of follow-up data to build on previous findings from this study.
35. News Note: Biomarker Can Distinguish Between Cell Death and DNA Damage
(Posted: 05/08/2009) - NCI researchers have identified a molecular ring pattern that could be used as a biomarker to identify and distinguish between cells that are programmed for death from cells that have a particular type of DNA damage. Such biomarkers could provide new tools for basic cellular biology research, but also help to mark cell death in clinical samples and monitor the efficacy of anticancer regimens.
36. Targeted Immune Cells Shrink Tumors in Mice
(Posted: 02/09/2009, Updated: 05/07/2009) - Researchers have generated altered immune cells that are able to shrink, and in some cases eradicate, large tumors in mice. The immune cells target mesothelin, a protein that is highly expressed, or translated in large amounts from the mesothelin gene, on the surface of several types of cancer cells.
37. New Early Detection Studies of Lung Cancer in Non-Smokers Launched Today
(Posted: 05/04/2009) - Government and private sector cancer scientists today launched a research partnership to find biomarkers for lung cancer that develops in people who have never smoked. The research studies are designed to create a better understanding of the biology of lung cancer and to develop a test to detect early-stage lung cancer in lifetime nonsmokers.
38. National Cancer Institute's Plan to Accelerate Cancer Research Announced
(Posted: 04/20/2009) - At the American Association for Cancer Research 100th Annual Meeting 2009 in Denver, NCI Director John E. Niederhuber, M.D., announced major details, such as funding more grants, development of a platform for personalized cancer care, and an accelerated cancer genetics program, that will move cancer research forward in this new economic environment.
39. Researchers Discover Potential Functional Role of Genetic Variation in Prostate Cancer Risk
(Posted: 04/20/2009) - Researchers have described how a common genetic variation may be involved in the development of prostate cancer. The variant occurs in a gene known to be involved in prostate function. The study, which included a team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, uncovered how a small change in the DNA of the gene impacts the biology of prostate cancer risk.
40. NCI MEDIA AVAILABILITY: Dr. John E. Niederhuber to Address the American Association for Cancer Research on NCI Plan to Accelerate Cancer Research
(Posted: 04/16/2009) - John E. Niederhuber, M.D., director of the NCI, addressed the American Association for Cancer Research 100th Annual Meeting 2009 in Denver Monday, April 20, 2009, during a Special Session. The talk focused on opportunities to hasten our progress against cancer and to conduct exciting new science, made possible, in part, by NCI's nearly three percent budget increase this year.
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